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GLP-1 drugs reduce glucagon levels, preventing unnecessary glucose release

Vitamin B12 uses intrinsic factor receptors, while B1 (Thiamine) uses THTR1/2 transporters

Tirzepatide adds a GIP receptor agonist component, but the gastric-motility effect is similar in clinical practice [1][2]

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The second indication of the drug was approved by the US FDA in January 2020

(30) suggesting that insulin resistance and glucose toxicity within the CNS of patients with T2D damages axon integrity, inhibits nerve impulses, and degrades myelin in oligodendrocytes, leading to cognitive dysfunction