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This modification makes the molecule more stable and resistant to breakdown in the GI tract
6.2 Potential pathophysiological mechanisms of gut microbiota and metabolite SCFAs in cytokine abnormalities SCFAs (such as acetate, propionate, and butyrate) activate receptors like FFAR2/3 and Gpr109a and inhibit histone deacetylase (HDAC), collectively suppressing the activation of the NF-B signaling pathway, thereby downregulating the expression of pro-inflammatory cytokines (202204)
Metabolism 24 (8), 15531564
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doi: 10.1007/s00134-020-05991-x 234 RushworthG
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