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This is one of the main reasons many clinicians advise limiting or avoiding alcohol, especially early on or during dose changes

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If you have medical conditions that require fluid restriction, follow your clinicians guidance

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This is typically the meal where reflux is worst, so keep portions smallest here

And when combined with semaglutide in the CagriSema combination , those GI numbers climbed even further, with 79.6% of participants experiencing some form of gastrointestinal event