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This mechanism is increasingly recognized as central to depression, anxiety, and cognitive decline
Khavinson VK, Razumovskii MI, Trofimova SV, Grigoryan RA, Chaban TV, Oleinik TL, et al
NO is synthesized by eNOS in endothelial cells and diffuses to vascular smooth muscle, where it activates the cytosolic form of guanylate cyclase (also known as guanylyl cyclase) to form cyclic guanosine monophosphate (cGMP)
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