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This adipose tissue accumulation is notably resistant to conventional weight loss strategies and is frequently associated with joint hypermobility.7,12 Symptoms often worsen throughout the day, particularly with heat exposure or prolonged standing, and are commonly accompanied by sensations of heaviness, tenderness, and discomfort in the affected areas.10,20 Notably, the S2k Guidelines emphasize that a disproportionate increase of adipose tissue on the extremities without corresponding symptoms shall not be diagnosed as lipedema

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Research ArticleInflammationMetabolismVascular biology Open Access | 10.1172/jci.insight.203211 1 Center for Thrombosis and Hemostasis (CTH), Medical Centre of the Johannes Gutenberg University, Mainz, Germany

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