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Based on the mechanism of skin irritation, we examined and proposed an approach to assess the skin irritation potential of copper compounds using cytotoxicity assay, gene and protein expression levels of cytokines
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In addition, the availability of novel cellular systems, such as cybrids or induced pluripotent stem cells, offers the chance to exploit the advantages of an in vitro investigation, although mirroring more closely the cell population being affected (Wang et al
Rees, R
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