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The hypothalamus increases somatostatin output in response to elevated serum GH, which suppresses pituitary GH secretion
Twice daily (morning + before bed): Doubles daily GH exposure
In unstimulated state, the activation loop (a-loop), containing the critical tyrosine (Y) residues 1131, 1135 and 1136, behaves as a pseudosubstrate that blocks the active site
