By comparing the gene expression profiles of the skin microbiota in acne patients with the profiles from healthy individuals, the vitamin B 12 biosynthesis pathway in the skin bacterium Propionibacterium acnes turned out to be significantly down-regulated in acne patients
These are typically hydrophobic compounds they have molecular structures with lots of nonpolar regions, so water (which is polar) repels them
Montagne A, Zhao Z, Zlokovic BV
The reconstituted solution is far less stable and MUST be stored in a refrigerator
Existing safety data is reassuring for supervised, cyclical use, but long-term continuous administration without professional oversight isnt something any reputable clinic would recommend
However, a new technology has emerged that allows glutathione to be delivered to cells through a simple swish and spray