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Once activated, these microglia release neurotoxic substances that further damage neuronal synapses and disrupt the synthesis of vital neurotransmitters like acetylcholine, dopamine, and serotonin

Brown found that the separation of breast cancer cells from the extracellular matrix (ECM) significantly decreased cell viability, whereas cell viability was improved by the ferroptosis inhibitor Fer-1, demonstrating that separation of cells from the ECM is a pro-ferroptosis response

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A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency

doi: 10.1038/s41477-018-0320-9 13 ClinicalTrials.gov (2025)