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Because its level in the blood is almost entirely dependent on the kidneys, it is a sensitive marker of renal function and is used to estimate GFR (Levey 1999)

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The standard diet was a purified feed (AIN-93 G, Research Diets, Inc.)

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In the Se-only supplementation studies, just one study included more subjects (420), while others included only up to 2080 subjects in total