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An agonist of a zinc-sensing receptor GPR39 enhances tight junction assembly in intestinal epithelial cells via an AMPK-Dependent mechanism

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ROS can induce damage to both nuclear and mitochondrial DNA through multiple mechanisms and also damage the integrity of mitochondrial permeability transition pore (mPTP), thereby aggravating the dysregulation of mitochondrial dynamics and the control of apoptosis (5052)