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A large number of bioactive molecules can be cleaved by DPP-4 in vitro , but only a few of these have been demonstrated to be physiological substrates

However, much of it is lost to stomach acid and enzymes on the way through the digestive tract

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Another breakthrough in obesity medication acceptance was the SELECT trial [7], the first cardiovascular outcome trial in persons with overweight and obesity with established cardiovascular disease (prior myocardial infarction, stroke or symptomatic peripheral artery disease) to show reduction in major adverse cardiovascular events (MACE) [7]

Today, there are three injectable GLP-1s available in the United States

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