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It does not produce systemic effects

Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase

[53+] Other animal and cell-based studies found that certain coffee components (kahweol and cafestol palmitates) increase the activity and production of GST and glutathione

Microscopy Roots of WT and GUS-reporter lines were cleared with a mixture of chloral hydrate, glycerol and water (8:1:2) and visualized/photographed under a Carl Zeiss Axiovert microscope equipped with differential interference contrast (DIC)

doi: 10.2165/00007256-200030030-00002

The simple answer is that nobody knows