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Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide
Filion, Michael A
You get very thirsty and you don't want to eat
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The benefits of macromolecular/supramolecular approaches in hydrogen sulfide delivery: a review of polymeric and self-assembled hydrogen sulfide donors
Animal studies have provided some mechanistic insights
For example, side effects for tirzepatide are significantly higher than other GLP-1RA which may impact food intake (3)
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