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Intraneuronal aggregates of -syn that are intracellularly localized and bound to cellular membranes are capable of triggering ferroptosis through these aggregate-membrane interactions ( 3.2 Relationship between PD-related genes/proteins and ferroptosis PD pathophysiology is significantly influenced by genetic predisposition, with numerous gene loci linked to its development (133)
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Archives of medical research, 2020
Gastroenterology 139 , 10081018 (2010)
We propose that these changes might be involved in the disease. Oxidative stress results from the accumulation of free radicals, highly reactive molecules that can damage cells, membranes, lipids, proteins and DNA
However, at present there is no consensus of an ideal protocol of reperfusion
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