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In a study involving temporarily induced insulin resistance through treatment of non-esterified fatty acid (NEFA), metformin improved extrahepatic glucose utilization in patients with T2DM potentially by promoting microvascular perfusion [50, 51]
Ziegler D, et al
Side effects can generally be avoided by starting at a low dose and increasing the dose very slowly
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If more than 2 days have passed, skip that dose and resume your normal weekly schedule the following week
10.4077/CJP.2018.BAG529 Chin J Physiol
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