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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (30, 112, 176, 207)

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Coupling antioxidant-assisted interventions with conventional physio-chemical removal procedures of AFs in food/feed items and developing GM PPs-rich crops are highly recommended to decrease the quantity of AFs to lowest concentrations and improve lifestyle and longevity of affected individuals

The first section contains a general quantitative description of the housing problem