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Three companies have stated publicly that they are actively developing lowerGWP pMDIs

The current global market size for anti-obesity medications (such as GLP-1RAs) was estimated by Goldman Sachs 7 to be c.$6bn

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Food Sci Nutr 13:e70094 Xie Y, Wu Y, Tao Q, Chen Y, Zeng C (2024) Causal effects of circulating glutamine on colitis, IBD, and digestive system cancers: a Mendelian randomisation study