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reported elevated circulating adiponectin and increased adipose tissue adiponectin expression, which were discussed in the context of obesity susceptibility and early leptin resistance, highlighting the context-dependent nature of adipokine regulation 40
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These findings were further supported by Nicolau et al 5 , who demonstrated similar clinical improvements in a broader cohort with extended follow-up, thereby reinforcing the potential use of GLP-1 RAs even in patients without metabolic comorbidities
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