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Discuss supplementation with your GP first, especially if you take regular medications or have other health conditions, and prioritise evidence-based lifestyle changes such as weight loss and dietary modification

Trustworthiness Evidence-based interpretation with clear follow-up pathways to reduce alarm

Expose the top of the arm (fig

Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports

Acetyl hexapeptide-8 Acetyl hexapeptide-8 (also known as acetyl hexapeptide-3 or Argireline) is a synthetic peptide that may act similarly to botulinum neurotoxins (Botox)

However, several limitations hinder their clinical efficacy