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GLP-1RAs have pleiotropic effects: they improve neurogenesis, reduce apoptosis, protect neurons from oxidative stress, and reduce neuroinflammation in various neurological conditions, and it is these beneficial effects that can be used in aging-related diseases, mainly AD and PD

Duration depends on condition: 24 weeks for ulcers 48 weeks for GERD Side Effects Common: Headache Nausea or abdominal discomfort Diarrhea or constipation Long-term use risks: Vitamin B12 deficiency Magnesium deficiency Increased risk of bone fractures Possible increased risk of infections (e.g., Clostridium difficile) Contraindications / Cautions Hypersensitivity to PPIs Use with caution in liver disease Avoid long-term unsupervised use Drug Interactions Can reduce absorption of drugs needing acidic pH (e.g., ketoconazole, iron)

10.1016/B978-0-443-19143-5.00039-6 236 RenH.HanR.ChenX.LiuX.WanJ.WangL.et al (2020)

Apnea is more common in people over 65