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Preclinical models indicate that the GLP-1 R system has evolved, at least in part, to regulate feeding-related motivation ( Repeated dosing is probably crucial for positive effects in depression and suicidality

To minimize risks of delayed emergence from anesthesia, aspiration, aspiration pneumonitis, and conversion to intubation, ceasing GLP-1 RA 14 days before surgery is optimal, the authors write

PMC 1141991