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It requires prescribers to extend the treatment conversation beyond the pharmacology
Note, the recent ESC guidelines recommending SGLT2i and GLP-1RA therapy do so irrespective of background metformin therapy
In a mouse study, selenium supplementation increased the expression and activity of certain enzymes related to glutathione [59]
However, the exogenous administration of GLP-1RAs can mitigate sympathetic excitability by suppressing the peripheral chemoreflex originating from the carotid body
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