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Although few studies have evaluated the expression of KP metabolites in postmortem samples, TDO protein expression was elevated in white matter glial cells in the anterior cingulate gyrus in samples from MDD patients [61], potentially contributing to localized neuroinflammation

(3) In addition, we calculated the interaction energy, E i(interaction) , defined as E i = E coul (electrostatic interaction) + E vdw (van der Waals interaction) , which typically indicates attractive forces in all-atom molecular dynamics simulations systems 44