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Regulating Satiety Pathways: In the hypothalamus, GLP-1 RAs stimulate neurons that promote satiety (POMC/CART neurons) and inhibit neurons that drive hunger (NPY/AgRP neurons), reducing food intake and enhancing fullness (Zheng et al., 2024)

doi:10.14740/jocmr3112w 61

Risk-benefit discussion of medication options

Biomarkers that should improve during GLP-1 treatment The biomarker news isn't all bad

Neuroendocrinology 68, 312318

When you design a randomized trial, you need to pick a primary outcome a single thing that you will use as the definitive test of whether your drug works or not

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