The route used in the majority of preclinical work and in most human case series
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Nat Commun 7:12150 Parker KH, Beury DW, Ostrand-Rosenberg S (2015) Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment
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Concurrently, an elevation in the levels of key lipolytic receptors, specifically beta-3-adrenergic receptors within adipocytes, was observed in these models