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It is very plausible that these patients that have poor blood glucose regulation have faults in their upper digestive tract and those bitter receptors and the sweet receptors that are regulating the production of the GIP and the GLP-1 may not be doing their thing properly or the L cells may be receiving the signal but are not healthy enough to produce enough GLP-1
2c and Extended Data Fig
At 12.5mg to 15mg (months 5 and beyond) Maximum receptor activation
It may be something upstream that is preventing any weight loss medication from working effectively
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