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In addition to KEAP1, which is the main negative regulator of NRF2 protein stability, many other factors which negatively regulate NRF2 have been discovered and characterized

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Polypharmacology is the basis for drug repurposing: this principle asserts that a drug with multiple targets can have multiple mechanisms of action (Nowak-Sliwinska et al., 2019)

Take 1 tube daily for best results