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103,104 Consequences include excessive ROS production, progressive lipid accumulation, mitochondrial swelling, cristae disruption, impaired -oxidation, fibrosis, inflammasome activation, and transition from steatosis to MASH

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In a series of papers [3436], Ookhtens and colleagues showed that the half-life of glutathione in the liver was quite low, approximately 23 hours, consistent with the result of Lauterburg [47]

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The ChaC family (ChaC1 and ChaC2, cytoplasmic glutathione-specific -glutamyl cyclotransferases) has recently been shown to take part in GSH metabolism