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doi: 10.1023/a:1018955126402
Accessed April 23, 2025
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Clinical trials show average weight loss of 10 to 15 percent of body weight over 68 weeks at the full 2.4 mg dose (per the STEP 1 trial published in the New England Journal of Medicine, 2021)
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We believe that Gs-coupled GPCRs in intestinal L-cells, the main pathway for GLP-1 secretion, could serve as novel drug targets by acting as primary signals for GLP-1 secretion
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