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Transcriptome analysis of the mouse cellular models of Ube3a deficiency has revealed differential gene expression associated with mitochondrial pathways [381]

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[9] Many factors can trigger or exacerbate oxidative stress, including: Chronic stress A lack of sleep A high-sugar, processed-foods-based diet Medications Environmental toxins and pesticides When oxidative stress occurs, the process can adversely impact the DNA, proteins, and lipids (fats) within our cells

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HDFA treatment had a negligible effect on glutathione metabolism