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Therapeutic Goods Administration (TGA), 2 december 2020
A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating
Abd Eldaim MA, Ibrahim FM, Orabi SH, Hassan A, El Sabagh HS (2018) l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF- and TGF-1
Factors that may influence perioperative management include: Medication characteristics : Daily GLP-1 medications (liraglutide, oral semaglutide) have shorter durations of action than weekly formulations (injectable semaglutide, dulaglutide, exenatide extended-release) [3] Risk factors : Higher doses, recent dose increases, active gastrointestinal symptoms, or known gastroparesis may increase risk [1] [3] Procedure type : More complex surgeries or those requiring general anaesthesia may warrant different approaches than minor procedures Individual patient factors : BMI, presence of diabetes, and other medical conditions Some anaesthetists may recommend temporarily pausing GLP-1 therapy before certain procedures, particularly for patients with additional risk factors
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Supplementary Table 1 )
