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This group of laxatives can therefore lead to melanosis coli, an increase in fat in the submucosa, atrophy of "smooth muscle and damage to intrinsic innervation.When there is a predominance of these last two aspects, the function of the large intestine is altered, as discussed elsewhere.The evidence of melanosis coli on a patient must immediately pose the problem on the harmful use of laxatives and symptoms of faecal stasis.In the absence of a history of abuse of anthraquinone laxatives, the finding of melanosis coli it requires further evaluation for the investigation of malignant neoplasm of the large intestine.