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Vitamin B12 overdose & toxicity
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The reported Km of glutathione reductase for GSSG is 65 mol /L and for NADPH 8.5 mol /L Erythrocyte lysates were incubated with a saturating concentration of GSSG (1 mmol /L) and either NADPH or NADH (100 mol /L)
The rare cases of rhabdomyolysis documented in the literature resolved after discontinuation of tirzepatide and supportive treatment, with no reports of permanent muscle damage
Published 2017 May 31
The receptor mechanism is identical
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