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BPC-157 exerts strong localized effects at the injury site, including tendon fibroblast proliferation, collagen synthesis upregulation, and NO-mediated vascular regulation within the wound microenvironment

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A review in JAAOS Global Research & Reviews mapped these peptides across PI3K/Akt, mTOR, TGF-, and AMPK signaling pathways, suggesting their role in musculoskeletal healing (Rahman, Lee & Seeds, JAAOS Global R&R , 2026)

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