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Work through incretin pathways that slow gastric emptying and enhance insulin secretion
For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)
Its neuroprotective properties calm overactive neural circuits without sedation, making it easier to transition into sleep naturally
For example, ITC-rich extracts of Moringa oleifera leaf (500 mg/kg administered 30 min prior to tests) induced anxiolytic effects in Swiss mice in lightdark and open field tests (OFT) (137)