The signaling pathways activated by endogenous GLP-1 and GLP-1RAs also differ based on their concentrations
Xu, E., Xie, Y
Most GLP-1 users (70%) said that their insurance paid for at least some of the cost of their GLP-1 medications
Cell Res 32 , 777780 (2022)
Wang C, Guo K, Gao D, Kang X, Jiang K, Li Y, Sun L, Zhang S, Sun C, Liu X, Wu W, Yang P, Liu Y
Retatrutide carries the side-effect profile of the GLP-1/GIP class nausea, vomiting, diarrhoea, constipation plus the class-level concerns we know from Mounjaro and Wegovy: gallbladder disease, pancreatitis, kidney injury from severe dehydration, and a possible thyroid C-cell tumour signal seen in rodent studies