This is partly due to the ABCG2 efflux pump, which transports sulfasalazine out of cells, reducing its absorption and effectiveness [205]
Toloza EM, Hunt K, Miller AR, McBride W, Lau R, Swisher S , Rhoades K, Arthur J, Choi J, Chen L, Chang P, Chen A, Glaspy J, Economou JS
10.1023/a:1007616817499 21
mtDAMPs activate neutrophils and monocytes, which infiltrate tissues and release additional ROS and proteases, causing further mitochondrial damage and cell death
Mitochondria are your cells power plants - tiny organelles that convert food and oxygen into ATP, your bodys energy currency
Thus, ferroptosis and other cellular processes involving phospholipid peroxidation can be regulated by controlling phospholipid peroxidation