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Factors That Affect How Long Semaglutide Stays in Your System While the average half-life is 7 days, several individual factors can shift the timeline slightly, such as kidney and liver function

Insulin dose was reduced after the initiation of the GLP-1 RA (2.2 IU/day at six months, p = 0.048)

Half-life can vary modestly between individuals based on kidney and liver function and other factors, so your personal clearance may run slightly faster or slower

10.1038/nm.4068 37 Ben-ZionZ.KoremN.SpillerT

Genetic defects affecting B12 processing and methylation

If the 2026 preprint holds up through peer review, neuroprotection becomes an equally valid rationale