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Bozzuto G, Molinari A

Mechanisms of Action and Therapeutic Applications of GLP-1 and Dual GIP/GLP-1 Receptor Agonists

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Acting on the Brains Appetite Centers: Semaglutide influences areas in the brain that regulate appetite, leading to reduced food intake and fewer cravings

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When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion The pancreas releases insulin in response to elevated blood glucose levels, but only when needed (glucose-dependent mechanism) Reduced glucagon release Glucagon, which raises blood sugar, is suppressed when glucose levels are adequate Delayed gastric emptying Food moves more slowly from the stomach into the intestines, promoting satiety Appetite regulation Signals to the brain's appetite centres reduce hunger and food intake Unlike naturally occurring GLP-1, which is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes, pharmaceutical GLP-1 receptor agonists are chemically modified to resist this degradation