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Acetaminophen is processed almost entirely by the liver through a process called conjugation

Myocardial injury and function: Among the outcome estimates, significant benefits were reported in 4 of 8 for left ventricular ejection fraction (LVEF), 10 of 17 for systolic blood pressure (SBP), 5 of 12 for LDL cholesterol, and 1 of 1 for final infarct size

Inhibition of cytochrome P450 enzymes by rhein in rat liver microsomes

Wang Y, Mu Y, Zhou XR, Ji HX, Gao X, Cai WW, et al

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If a provider is vague about this, thats a warning sign