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With 28.3% average weight loss in 2,339 adults, 45.3% achieving 30% loss, and a discontinuation rate of just 11.3% this remains the most comprehensive and compelling single dataset behind retatrutide's path to approval

While further research is needed to define their role in inflammatory diseases, this remains a promising and rapidly evolving area of endocrinology

Liver fat content reduction reached approximately 80 percent at higher dose tiers an outcome that, researchers have observed, has redirected research interest toward the compound's potential in MASLD/MASH research contexts (PMID 38858523)

Some users experienced side effects such as nausea, vomiting, diarrhea, stomach problems, and gastrointestinal problems

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These typically include nausea, vomiting, diarrhoea, abdominal pain, and reduced appetite