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4.5 Overcoming drug resistance through nanocarrier-mediated gene therapy Non-coding RNAs, including miRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play critical roles in the development of chemoresistance in osteosarcoma, and their modulation using nanoparticle delivery systems represents a novel therapeutic approach (6264)

Code year: FY2026 (Oct 1 2025 Sep 30 2026) Audience: Certified Coders, Auditors and Clinical Documentation Specialists Access: CCO Members Last updated: April 2026 Definition Deep vein thrombosis (DVT) is the formation of a blood clot (thrombus) within a deep vein, most commonly in the lower extremities the femoral, popliteal, iliac, tibial, or peroneal veins but also occurring in the upper extremities (brachial, radial, ulnar, axillary, subclavian, internal jugular veins) and less commonly in other sites (vena cava, renal vein, hepatic vein, cerebral sinuses)

Sapienza J, Agostoni G, Comai S, Nasini S, DallAcqua S, Sut S, Spangaro M, Martini F, Bechi M, Buonocore M, Bigai G (2024) Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise

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