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Common side effects include nausea, vomiting and constipation, particularly during dose escalation
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subsequent doses should continue as scheduled
The developmental path of GLP-1 receptor agonists is not covered in this article
The primary endpoint was major adverse cardiovascular events (MACE), defined as cardiovascular death, nonfatal heart attack, or nonfatal stroke
Ispaghula is generally well tolerated, though it must always be taken with adequate fluid (at least 200ml per dose) to prevent oesophageal or intestinal obstruction
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