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All observations remain limited to controlled laboratory environments and do not represent therapeutic effects or clinical applications

These interactions range from transient 'kiss-and-run' contacts supporting rapid lipid flux to stable anchors (90), which supports high-demand processes such as thermogenesis in brown adipocytes (91)

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Patients who've plateaued on semaglutide are excellent tirzepatide candidates, as the added GIP receptor mechanism provides pharmacologic activity the prior medication didn't achieve

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