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Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes

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Exclusion criteria encompassed patients with scheduled orthopedic surgery due to walking limitations, peripheral revascularization within the last 180 days, recent acute myocardial infarction (AMI) or stroke, hospitalization for angina or transient ischemic attack (TIA) in the last 180 days, and renal function below 30 mL/min/1.73 m