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It has been shown that 510% total body weight loss is associated with a reduction in the risk of various metabolic, skeletal, and anatomical complications of obesity [21]

Although the latter effect may account for as much as 50% of the peptides hypoglycaemic action [6], the underlying cellular mechanism(s) remain(s) poorly understood

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Participants in the SGLT2i group demonstrated improvement in renal function with an increase in mean eGFR over the 5-year follow-up period (+3.5 ml/min per 1.73 m 2 ), compared with an overall reduction in eGFR in the GLP-1 RA cohort (7.2 ml/min per 1.73 m 2 )

Lactic acidosis in patients with diabetes treated with metformin