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Of note, oxidative stress serves as another crucial inductive factor of apoptosis (72, 111)

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2 Pathophysiological mechanisms of oxidative stress in MIRI 2.1 Concept and dynamic changes of oxidative stress in MIRI Oxidative stress is fundamentally defined as an imbalance between the production of ROS and the capacity of the bodys antioxidant defense systems to neutralize them (Figure 1) (Jaganjac et al., 2022)