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GLP-1RAs are a relatively new class of injectables that are effective at reducing HbA 1c , have a low risk of hypoglycaemia when given as monotherapy or in the absence of sulphonylureas (SU) or insulin, and have the potential for weight losskey considerations when treating a typical obese patient with T2DM [4]

This hormone plays a critical role in maintaining the gut barrier and regulating inflammation.F By improving gut barrier integrity, Semaglutide may help prevent leaky gut syndromea condition where harmful substances escape from the digestive tract into the bloodstream, triggering widespread inflammation

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appetite suppression through MC4R reduces food intake

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To determine whether exendin-4 treatment exerts effects on atrial electrophysiology, the APDs and atrial tachyarrhythmia inducibility were measured in Langendorff-perfused hearts