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Critically, sophisticated EEG analysis confirmed no sedation in the classical pharmacological sense establishing that DSIP sustains natural sleep functions rather than inducing pharmacological sedation

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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema